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Furthermore, pilot studies or studies in highly specialized populations (such as elite athletes) often have smaller sample sizes due to the difficulty of recruiting participants who meet the strict inclusion criteria
Mitochondrial dysfunction has emerged as a crucial factor in the pathogenesis of various diseases, including DE, highlighting the complex relationship between DE and mitochondrial dysfunction
Studies have shown that mesenchymal stem cells (MSCs) prior to becoming adipogenic, mTORC1-activated (phosphorylated) S6K1 enters the nucleus (61, 62), recruits enhancer of zeste homolog 2 (EZH2) to histone 3 (H3), mediating H3K27 trimethylation (H3K27me3) at Wnt gene loci (62), ultimately resulting in Wnt target gene suppression that facilitates adipogenesis (Figure 3) (63)
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