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Shi N, He J, Guo Q, Liu T, Han J

One hypothesis is that chronic GIP receptor agonism desensitizes the GIP receptor, creating an antagonism, which ultimately leads to weight loss

Weight Loss Drug Comparison: Efficacy, Muscle Loss, and Market Stage Towards a Dual-Action Approach: Fat Loss and Muscle Preservation Recognizing the need for a more balanced approach to weight management, pharmaceutical innovators are now focusing on therapies that not only promote fat loss but also preserve or enhance muscle mass (Rodgers and Christopher 2022)