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The strongest published finding is from the foundational Biochemical Pharmacology study by Neelakantan et al.: in diet-induced obese mice, daily 5-Amino-1MQ administration produced reductions in body weight, white adipose tissue mass, and adipocyte size without any significant change in food intake
By contrast, giving B to people with normal levels does not boost energy or metabolism beyond normal
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Using B12 injections outside clinical necessity exposes patients to unnecessary risks without proven benefit
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