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Subsequently, it declined steadily: 4.6 1.88 on day 2 ( P = 0.389), 3.57 2.43 on day 3 ( P = 0.036), 4.14 2.01 on day 4 ( P = 0.127), 4.07 2.21 on day 5 ( P = 0.127), 4.14 1.91 on day 6 ( P = 0.136) and 3.14 1.75 on day 7 ( P = 0.003)
Therefore, considering the overlapping yet distinct roles of insulin and IGF-1 in the brain, disruptions in their signaling pathways due to IR may contribute to the neurobiological mechanisms underlying depression in individuals with T2DM
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